This vérité documentary follows the long struggle of two inmates at a mental institution in Siberia. Like many of their fellow residents, Yulia and Katia have been transferred from the orphanage to a confined neuropsychiatric unit, and are legally incapacitated and deprived of all civil rights, including freedom, and therefore the possibility of establishing a family, or earning a wage. They have spent much of their lives locked in various institutions, abandoned by their mothers, raised with little access to vital therapy and programs, and caught in an impersonal bureaucracy that prevents them from taking control of their own lives. Well-meaning staff members encourage them to think positively, but speak of the women openly presuming their cognitive impairments. Between hopes and disappointments, 'Liberation, the User's Guide' is the tale of their rocky path toward regaining their basic rights to independence.